Key result
Diabetic rabbit kidneys exhibit decreased endothelium-dependent vasodilation to acetylcholine and bradykinin versus normal controls.
Why the study?
The study aimed to evaluate endothelium-dependent vasodilatation in diabetic kidneys due to unclear effects of diabetes on renal endothelial function.
Population
Rabbit kidneys, normal and diabetic (three weeks after 150 mg alloxan, intraperitoneally)
Comparison
Diabetic kidneys vs normal kidneys in response to acetylcholine and bradykinin
Design
Preclinical perfusion study with dose-response vasodilation assessment
Authors
Loading...
Hypothesis-generating for renal endothelial dysfunction in diabetes; leaves open relevance to human disease and should not change practice.
p-value: p=<0.05 for Ach, <0.01 for Bk
Alloxan-induced diabetes in rabbits impairs endothelium-dependent vasodilation in the kidneys while preserving endothelium-independent vasodilation.
Forti et al. (1998) studied Diabetes. Alloxan-induced diabetes vs. Normal controls was evaluated on Vasodilator response to acetylcholine (Ach) and bradykinin (Bk) (p=<0.05 for Ach, <0.01 for Bk). Alloxan-induced diabetic rabbit kidneys exhibited a decreased endothelium-dependent vasodilator response to acetylcholine (p < 0.05) and bradykinin (p < 0.01) compared to normal controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: