What question did this study set out to answer?

To determine the role of leptin in the development of obesity and type 2 diabetes by evaluating circulating leptin concentrations and their relationship to metabolic parameters in SHR/N-cp rats.

January 1, 2001Journal of Diabetes ResearchOpen Access

Leptin and Its Relation to Obesity and Insulin in the SHR/N‐corpulent Rat, A Model of Type II Diabetes Mellitus

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Authors

MVManuel T. VelasquezGeorge Washington University SBSam J. BhathenaNational Institutes of Health CHCarl T. HansenNational Institutes of Health

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Implication

Animal study demonstrates marked hyperleptinemia linked with insulin resistance in SHR/N-corpulent rats, suggesting leptin upregulation drives diabesity metabolic syndrome.

Key Points

To determine the role of leptin in the development of obesity and type 2 diabetes by evaluating circulating leptin concentrations and their relationship to metabolic parameters in SHR/N-cp rats.
Measured steady-state fasting plasma leptin, insulin, glucose, cholesterol, and triglyceride levels in obese and lean SHR/N-cp rats at the stage of established obesity.
Assessed relationships between plasma leptin, body weight, and metabolic risk variables across animal groups using Spearman correlation analysis.
Mean fasting plasma leptin was 8-fold higher (p < 0.01) and insulin was 6-fold higher in obese rats compared to lean controls, alongside significantly higher fasting glucose, cholesterol, and triglycerides.
Plasma leptin correlated positively with body weight (r = 0.73, p < 0.01), fasting plasma glucose (r = 0.75, p < 0.05), total cholesterol (r = 0.63, p < 0.05), and triglycerides (r = 0.67, p < 0.05).
Plasma leptin correlated positively with plasma insulin across all animals (r = 0.70, p < 0.01) and within lean rats (r = 0.59, p < 0.05), but not within obese rats (r = 0.23, p = NS).

Cite This Study

Velasquez et al. (2001) studied this question.

synapsesocial.com/papers/6aacfa82dbc146fad4370f15 https://doi.org/10.1155/edr.2001.217

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Implication

Animal study demonstrates marked hyperleptinemia linked with insulin resistance in SHR/N-corpulent rats, suggesting leptin upregulation drives diabesity metabolic syndrome.

Leptin and Its Relation to Obesity and Insulin in the SHR/N‐corpulent Rat, A Model of Type II Diabetes Mellitus

Discussion

Member takes

Implication

Key Points

Cite This Study

Leptin and Its Relation to Obesity and Insulin in the SHR/N‐corpulent Rat, A Model of Type II Diabetes Mellitus

Discussion

Member takes

Implication

Key Points

Cite This Study

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