Key result
Respiratory viruses occur in ~53% of children hospitalized with acute respiratory infections, primarily influenza A.
Why the study?
Acute respiratory tract infection is a major cause of morbidity and mortality in children, with various viruses contributing to disease but their prevalence in hospitalized children was not fully characterized.
Cross-Sectional (n=340)
No
Answers are grounded in this paper and cite their sources.
Over half of children hospitalized with acute respiratory tract infections had detectable viral pathogens, predominantly influenza A and adenovirus, highlighting the significant role of viral infections in this population.
Background: Acute respiratory tract infection (ARTI) is a significant cause of morbidity and mortality among children worldwide. The majority of acute respiratory infections in children are caused by viruses, with respiratory syncytial virus (RSV) being the most frequently encountered. Other important viral pathogens include human metapneumovirus, human coronaviruses, adenovirus, and influenza. These infections can lead to complications such as bronchitis and pneumonia. So, this study aimed to evaluate the prevalence of influenza viruses A and B, adenovirus, respiratory syncytial virus (RSV), and human metapneumovirus (HMPV) in children with ARTI. Methods: The molecular diagnostic of polymerase chain reaction approach was used to detect influenza (A and B), metapneumovirus, respiratory syncytial virus (RSV), and adenovirus in respiratory samples of children with acute respiratory infection hospitalization in a teaching hospital of the Shiraz University of Medical Sciences in January 2016-March 2017. Results: Of the 340 patients examined, 208 (61.20%) were male and the median age was 3.13 ± 2.38 years. Respiratory viruses were found in 179 (52.64%) patients. The male-to-female ratio was 1.63 : 1 in patients who were viral positive. Detection rates for influenza A, adenovirus, influenza B, RSV, and HMPV were 28.23%, 24.70%, 8.52%, 3.23%, and 2.64%, respectively, and coinfections were detected in 24.02%. The most common combination of two-virus coinfections was IFVA/AdV, followed by IFVB/AdV, AdV, IFVB/IFVA, RSV/IFVA, HMPV/AdV, RSV/AdV, and HMPV/IFVA. Conclusion: The high prevalence of respiratory viruses in children hospitalized with ARTI suggests that viral infection may play a role in disease pathogenesis. This should be confirmed through the conduct of case-control studies and may inform the role of vaccination to prevent respiratory viral infections.
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Farzi et al. (2024) conducted a cross-sectional in Acute respiratory tract infection (ARTI) (n=340). Respiratory viruses (Influenza A and B, Adenovirus, RSV, HMPV) was evaluated on Prevalence of respiratory viruses. Respiratory viruses were detected in 52.64% of children hospitalized with acute respiratory tract infection, with influenza A and adenovirus being the most prevalent.
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