Key result
AF complicating ACS is linked to ~170% higher in-hospital mortality versus no AF.
Why the study?
There is a paucity of data on atrial fibrillation complicating acute coronary syndrome in Arabian Gulf countries.
Does atrial fibrillation increase mortality in patients hospitalized with acute coronary syndrome?
Cohort (n=7,930)
Yes
Does atrial fibrillation increase mortality in patients hospitalized with acute coronary syndrome?
Odds Ratio: 2.7
p-value: p=<0.001
Atrial fibrillation complicating acute coronary syndrome is associated with significantly higher short- and long-term mortality.
AF complicating ACS signals elevated mortality risk; confirms association in real-world data but leaves open whether targeted interventions improve outcomes.
There is a paucity of data on atrial fibrillation (AF) complicating acute coronary syndrome (ACS) in Arabian Gulf countries. Thus, we assessed the incidence of AF in patients with ACS in these countries and examined the associated in-hospital, 30-day, and 1-year adverse outcomes. The population comprised 7930 patients enrolled in the second Gulf Registry of Acute Coronary Events (Gulf RACE-2). Of 7930 patients with ACS, 217 (2.7%) had AF. Compared with patients without AF, patients with AF were less likely to be male (65.9 vs 79.1%) and were older (mean age 64.6 vs 56.6 years). Compared with patients without AF, in-hospital, 30-day, and 1-year mortality were significantly higher in patients with any AF (odds ratio [OR]: 2.7, 2.2, 1.9, respectively; P < .001) and in patients with new-onset AF (OR: 5.2, 3.9, 3.1, respectively; P < .001. In conclusion, AF in patients with ACS was associated with significantly higher short- and long-term mortality.
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Hersi et al. (2011) conducted a cohort in Acute Coronary Syndrome (n=7,930). Atrial fibrillation vs. No atrial fibrillation was evaluated on In-hospital mortality (OR 2.7, p=<0.001). Atrial fibrillation complicating acute coronary syndrome was associated with significantly higher in-hospital, 30-day, and 1-year mortality compared to patients without AF (OR 2.7, 2.2, 1.9; P<0.001).
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