Comparative Effects of Root Canal Irrigation with Sodium Hypochlorite and Super-oxidized Water on Post-Endodontic Pain in Single-Canal Teeth: A Clinical Trial

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Background and Aim: This study aimed to compare the effects of root canal irrigation with sodium hypochlorite (NaOCl) and superoxidized water on post-endodontic pain in single-canal teeth.Materials and Methods: This double-blind randomized clinical trial was conducted on 72 patients with irreversible pulpitis of single-canal teeth.The patients were randomly assigned to two groups (n=36) for root canal irrigation with either 1% NaOCl or 50% super-oxidized water during endodontic treatment.The root canals were instrumented by the step-back technique with a minimum and maximum apical preparation size of 30 and 50, respectively, and flaring by 5 files larger than the master apical file.Patients' pain level was quantified at 6, 12, 24, 48, and 72 hours, and 7 days postoperatively using a visual analog scale (VAS).Root canal treatments were accomplished in two sessions, and calcium hydroxide was applied as intracanal medicament.Data were analyzed by the Mann-Whitney test (alpha=0.05).Results: At 12 hours postoperatively, the pain score was significantly higher in the NaOCl group than the super-oxidized water group (P=0.043).The pain score gradually decreased in both groups after 12 hours with no pain recorded at 7 days.The difference in pain score between the two groups was not significant at any other time point (P>0.05).Conclusion: The present results revealed significantly lower level of pain at 12 hours post-treatment of single-canal teeth in root canal irrigation with super-oxidized water.