Validity of diagnoses of cardiac malformations in a Danish population-based hospital-discharge registry
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Implication
Validation study finds an 89% positive predictive value for cardiac malformations in registered children, highlighting the registry's utility for birth defect risk research.
Key Points
- To evaluate the validity, expressed as positive predictive value, of discharge diagnoses of cardiac malformations in the population-based North Jutland County Hospital Discharge Registry.
- Reviewed the medical records of 418 of 423 children (99%) with a first-time discharge diagnosis of cardiac malformation registered between January 1, 1994, and March 31, 2002, in Denmark.
- Calculated the overall and lesion-specific positive predictive values along with the birth prevalence rate.
- Record review confirmed cardiac malformations in 372 children, yielding an overall positive predictive value of 89% (95% CI 86%, 92%) and a prevalence rate of 7.6 per 1,000 live births.
- Positive predictive values ranged from 82% to 86% for three of the four most common malformations, but reached only 41% for patent arterial duct.
Cite This Study
Jepsen et al. (2006) studied this question.