Key result
MVP is linked to ~28% longer inter-atrial electromechanical delay versus healthy controls.
Why the study?
Atrial arrhythmias are frequently observed in symptomatic patients with mitral valve prolapse, but the prolongation of atrial electromechanical delay in these patients was not evaluated.
Is atrial electromechanical delay prolonged in patients with mitral valve prolapse compared to healthy controls?
Case-Control (n=80)
Is atrial electromechanical delay prolonged in patients with mitral valve prolapse compared to healthy controls?
Absolute Event Rate: 31.6% vs 24.7%
p-value: p=0.001
Patients with mitral valve prolapse exhibit prolonged atrial electromechanical delay and P-wave dispersion, suggesting a potential mechanism for their increased risk of atrial arrhythmias.
May link mitral valve prolapse to arrhythmia risk via conduction delay; hypothesis-generating, needs prospective validation.
Atrial arrhythmias are seen frequently in symptomatic patients with mitral valve prolapse (MVP). The purpose of our study was to evaluate whether the atrial electromechanical delay (AEMD) measured by tissue Doppler imaging (TDI) is prolonged in patients with MVP. A total of 40 patients with MVP (16 males/24 females, 33.4 ± 6.1 years), and 40 controls (18 males/22 females, 34.2 ± 4.2 years) were included in the study. Inter-AEMD and intra- AEMD were measured by TDI. P-wave dispersion (PWD) was calculated from the 12-lead electrocardiogram. Inter-AEMD and intra-AEMD were significantly longer in patients with MVP than in the controls (31.6 ± 12.1 vs 24.7 ± 5.4 ms, p = 0.001 and 8.1 ± 5.3 vs. 5.7 ± 1.9 ms, p = 0.008; respectively). PWD was significantly longer in patients with MVP than in the controls (41.3 ± 7.1 vs 34.7 ± 4.3 ms, p<0.0001). The left atrial (LA) diameter, anterior and posterior mitral leaflet thicknesses were significantly higher in patients with MVP than in the controls. (35.4 ± 3.0 vs 31.9 ± 3.0 mm, p<0.0001 and 3.6 ± 0.9 vs 2.8 ± 0.7 mm, p<0.0001 and 2.9 ± 0.7 vs 2.2 ± 0.4 mm p<0.0001; respectively). Inter-AEMD was positively correlated with PWD, mitral leaflet thickening and LA diameter. We showed that AEMD is significantly prolonged in patients with MVP, and speculated that this prolongation may reflect the increase of the risk of atrial arrhythmias in MVP subjects.
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Açıkgöz et al. (2011) conducted a case-control in Mitral valve prolapse (n=80). Mitral valve prolapse vs. Healthy controls was evaluated on Inter-atrial electromechanical delay (Inter-AEMD) (p=0.001). Patients with mitral valve prolapse had significantly prolonged inter-atrial electromechanical delay compared to controls (31.6 vs 24.7 ms, p=0.001).
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