Key result
SGLT2 inhibitor therapy significantly reduced mean pulmonary artery pressure by 3.06 mmHg after 10 weeks in patients with advanced chronic heart failure.
Why the study?
Right ventricular pacing may cause electrical and mechanical desynchrony leading to impaired LVEF, and the outcomes of His bundle pacing and left bundle branch pacing compared with RVP were unclear.
Does His bundle pacing or left bundle branch pacing improve clinical and physiological outcomes compared to right ventricular pacing in patients requiring a de novo permanent pacemaker for bradyarrhythmia?
Observational (n=17)
No
Does His bundle pacing or left bundle branch pacing improve clinical and physiological outcomes compared to right ventricular pacing in patients requiring a de novo permanent pacemaker for bradyarrhythmia?
Mean Difference: -3.06
p-value: p=0.014
Conduction system pacing (HBP and LBBP) is superior to right ventricular pacing in maintaining physiological ventricular activation and reducing heart failure hospitalizations, though it requires longer procedure times and carries a higher risk of lead revision with HBP.
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Kirschbaum et al. (2021) conducted an observational in Chronic heart failure (n=17). SGLT2 inhibitors (Dapagliflozin or Empagliflozin) vs. Baseline was evaluated on Change in mean pulmonary artery pressure (MD -3.06 mmHg, p=0.014). SGLT2 inhibitor therapy significantly reduced mean pulmonary artery pressure by 3.06 mmHg after 10 weeks in patients with advanced chronic heart failure.
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