Key result
Constitutive modeling captures porcine tricuspid valve stress-strain responses and reveals high anisotropy indices under 0.5.
Why the study?
Quantification of the mechanical properties of tricuspid valve leaflets is a key step in developing computational models for understanding valve function and improving surgical procedures and devices.
This study provides quantified material constants for porcine tricuspid valve leaflets, enabling more accurate computational models for understanding valvular function and developing medical devices.
Porcine tricuspid leaflet constants may refine valve simulations; leaves open human validation before clinical use.
The tricuspid valve is a one-way valve on the pulmonary side of the heart, which prevents backflow of blood during ventricular contractions. Development of computational models of the tricuspid valve is important both in understanding the normal valvular function and in the development/improvement of surgical procedures and medical devices. A key step in the development of such models is quantification of the mechanical properties of the tricuspid valve leaflets. In this study, after examining previously measured five-loading-protocol biaxial stress-strain response of porcine tricuspid valves, a phenomenological constitutive framework was chosen to represent this response. The material constants were quantified for all three leaflets, which were shown to be highly anisotropic with average anisotropy indices of less than 0.5 (an anisotropy index value of 1 indicates a perfectly isotropic response, whereas a smaller value of the anisotropy index indicates an anisotropic response). To obtain mean values of material constants, stress-strain responses of the leaflet samples were averaged and then fitted to the constitutive model (average R2 over 0.9). Since the sample thicknesses were not hugely different, averaging the data using the same tension levels and stress levels produced similar average material constants for each leaflet.
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Khoiy et al. (2018) studied this question. Phenomenological constitutive modeling was evaluated on Material constants and anisotropy index. Porcine tricuspid valve leaflets were shown to be highly anisotropic with average anisotropy indices of less than 0.5, and their stress-strain responses were successfully fitted to a constitutive model.
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