What is the clinical evidence from this study?

Population: Tricuspid valve mechanics (n=8). Intervention: Passive ex vivo beating heart model. Primary outcome: Peak areal strain at the midsection of the valve leaflets.

What question did this study set out to answer?

To measure dynamic surface deformation of tricuspid valve septal leaflets in an intact, ex vivo beating heart model without dissecting or remounting the valve annulus.

September 6, 2016Journal of Biomechanical Engineering

Surface Strains of Porcine Tricuspid Valve Septal Leaflets Measured in Ex Vivo Beating Hearts

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Key result

In a passive ex vivo beating porcine heart model, the peak areal strain at the midsection of the tricuspid valve leaflets was 9.8 ± 2.0%.

Population

Porcine hearts (n = 8)

Design

Preclinical

Authors

KKKeyvan Amini KhoiyUniversity of Akron DBDipankar BiswasJohns Hopkins University TDThomas N. DeckerUniversity of Akron

Discussion

Member takes

Implication

Offers quantitative strain data for tricuspid valve modeling; leaves open in vivo human validation.

Key Points

To measure dynamic surface deformation of tricuspid valve septal leaflets in an intact, ex vivo beating heart model without dissecting or remounting the valve annulus.
Mounted intact porcine hearts (n = 8) in a passive ex vivo system preserving native atrioventricular valve annular geometry.
Connected right ventricular apexes to a pulse-duplicator pump to reproduce physiological right ventricular pressure waveforms and pulsatile flow through the tricuspid and pulmonary valves.
Midsection peak areal strain of the septal leaflets reached 9.8 ± 2.0% (mean ± standard error).
Directional peak strains reached 5.6 ± 1.1% in the circumferential axis and 4.3 ± 1.0% in the radial axis, closely mirroring in vivo values documented for other atrioventricular valves.

Structured PICO

Population

8 porcine hearts evaluated in a passive ex vivo beating heart model to measure tricuspid valve leaflet deformation.

Intervention

Measurement of leaflet deformation in a passive ex vivo beating heart connected to a pulse-duplicator pump

Outcome

Peak areal strain, circumferential strain, and radial strain of the tricuspid valve septal leafletssurrogate

This novel ex vivo technique successfully measured porcine tricuspid valve leaflet strains without isolating the valve annuli, providing baseline physiological deformation values.

Cite This Study

Khoiy et al. (2016) studied Tricuspid valve mechanics (n=8). Passive ex vivo beating heart model was evaluated on Peak areal strain at the midsection of the valve leaflets. In a passive ex vivo beating porcine heart model, the peak areal strain at the midsection of the tricuspid valve leaflets was 9.8 ± 2.0%.

synapsesocial.com/papers/6a70647f75498292b709d0ea https://doi.org/10.1115/1.4034621

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