Key result
Ultrafiltration drives ~1.2 kg greater weight loss vs control in ADHF but increases serum creatinine.
Why the study?
Controversy remains regarding the efficacy and renal tolerability of ultrafiltration for treating acute decompensated heart failure.
Does ultrafiltration improve weight loss and fluid removal in patients with acute decompensated heart failure?
Population
1281 patients with acute decompensated heart failure from 19 randomized controlled trials
Comparison
Ultrafiltration vs control treatments
Design
Meta-analysis of randomized controlled trials
Authors
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Ultrafiltration aids short-term decongestion in ADHF despite rising creatinine; extends surrogate evidence while underscoring renal risks for future trials.
Meta-Analysis (n=1,281)
Does ultrafiltration improve weight loss and fluid removal in patients with acute decompensated heart failure?
Mean Difference: 1.24 (95% CI 0.38–2.09)
p-value: p=0.004
In patients with acute decompensated heart failure, ultrafiltration improves fluid removal and weight loss compared to control treatments but worsens renal function without improving long-term clinical outcomes.
Liu et al. (2021) conducted a meta-analysis in Acute decompensated heart failure (n=1,281). Ultrafiltration vs. Control treatments was evaluated on Weight loss (WMD 1.24, 95% CI 0.38-2.09, p=0.004). Ultrafiltration in patients with ADHF was superior to control treatments for weight loss (WMD 1.24 kg; 95% CI 0.38-2.09; P=0.004) and fluid removal, but increased serum creatinine.
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