Key result
Pregnancy is linked to progressively increased brachial artery diameter and FMD peaking in the last trimester.
Why the study?
The endothelial function changes during pregnancy and its assessment by flow-mediated dilatation (FMD) have implications for understanding vascular adaptations and preeclampsia.
Does pregnancy alter endothelial function as measured by flow-mediated dilatation in normotensive women?
Cohort (n=548)
No
Does pregnancy alter endothelial function as measured by flow-mediated dilatation in normotensive women?
p-value: p=<0.001
Pregnancy is associated with a progressive and significant increase in brachial artery diameter and flow-mediated dilatation, reflecting enhanced endothelial function.
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Supports enhanced endothelial function in normotensive pregnancy; leaves open effects on maternal cardiovascular risk and need for validation.
Sierra-Laguado et al. (2006) conducted a cohort in Pregnancy (n=548). Pregnancy vs. Non-pregnant women was evaluated on Flow Mediated Dilatation (FMD) (p=<0.001). Pregnancy is associated with a progressive increase in brachial artery diameter and flow-mediated dilatation, reaching the highest value during the last trimester (p<0.001).
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