Key result
Excisional biopsy and immunohistochemical evaluation reveal a rare dedifferentiated liposarcoma in a young woman's thigh.
Why the study?
Dedifferentiated liposarcoma is mostly seen in the retroperitoneum, and data for its occurrence in the lower extremities are very limited.
Case Report (n=1)
Highlights a rare case of dedifferentiated liposarcoma presenting in the lower extremity, emphasizing the need for immunohistochemical evaluation for definitive diagnosis.
Raises suspicion for dedifferentiated liposarcoma in young adults with thigh masses; single case report leaves open diagnostic algorithms.
INTRODUCTION: Liposarcoma is generally classified into four subtypes: a) well-differentiated liposarcoma/atypical lipomatous tumor, b) dedifferentiated liposarcoma, c) myxoid/round cell liposarcoma, and d) pleomorphic liposarcoma. Dedifferentiated liposarcoma is mostly seen in the region of retroperitoneum. AIM: To present a case of dedifferentiated liposarcoma in a rare site of location: the lower extremity. CASE REPORT: A 24-year-old woman presented with a firm painful mass, 3x2 cm in diameter on the medial side of left thigh. MRI demonstrated a lesion on that location showing low signal intensity on T1-wieghted and high signal intensity on T2A-wieghted sequences. After an excisional biopsy the histopathological examination via Haematoxylin and Eosin firstly revealed the diagnosis of malign undifferentiated tumor. The results of immunohistochemical evaluations were as follows: SMA (-), HMB45 (-), S100 (+, focally), Desmin (-), Vimentin (+, focally), CD68 (+, focally), CD34 (-), LCA (-), and Inhibin (-). The final histopathological diagnosis was dedifferentiated liposarcoma. CONCLUSIONS: In English-language literature data for dedifferentiated liposarcoma of the lower extremities are very restricted. Although imaging with CT and MRI, the final and distinct diagnosis is made immunohistochemically. A clinician should be aware of the presence of a dedifferentiated liposarcoma within a mass on the lower extremities.
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Şengül et al. (2019) conducted a case report in Dedifferentiated liposarcoma (n=1). Excisional biopsy and immunohistochemical evaluation was evaluated on Histopathological diagnosis. Excisional biopsy and immunohistochemical evaluation of a firm painful mass on the left thigh of a 24-year-old woman revealed a rare case of dedifferentiated liposarcoma.
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