Key result
Microdialysis strongly correlates with tissue biopsies for monitoring energy metabolites in a porcine heart model.
Why the study?
The validity of the microdialysis technique for experimental in vivo studies of myocardial energy metabolism was not known.
Effect estimate: r = 0.90 for lactate
p-value: p=<0.001
The microdialysis technique provides valid measurements of dynamic changes in myocardial energy metabolism, correlating strongly with tissue biopsies in a porcine model.
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Microdialysis correlates with biopsies for myocardial metabolites in porcine ischemia; supports experimental validation but leaves clinical translation open.
Kavianipour et al. (2003) studied Myocardial ischaemia and reperfusion (n=23). Microdialysis technique vs. Tissue biopsies was evaluated on Correlation between interstitial levels of energy-related metabolites monitored by microdialysis and tissue biopsy levels (r = 0.90 for lactate, p=<0.001). Interstitial levels of energy-related metabolites monitored by microdialysis correlated significantly with tissue biopsy levels (e.g., lactate r=0.90, P<0.001) in a porcine heart model.
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