Key result
NOS-I155 sharply peaks during synaptogenesis onset in developing rodent brains before declining.
Why the study?
Expression and activity of neuronal nitric oxide synthase type I (NOS-I155) are low or undetectable in developing brain, and its induction during synaptogenesis is not well characterized.
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Transient NOS-I induction during rodent synaptogenesis is hypothesis-generating; leaves open its role in human brain development.
Ogilvie et al. (1995) studied Developing mouse and rat brain. Synaptogenesis and brain development was evaluated on NOS-I155 expression and activity. Neuronal nitric oxide synthase type I (NOS-I155) is sharply induced coincident with the onset of synaptogenesis in specific brain regions of developing mice and rats, followed by a decrease.
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