Transient nitric oxide synthase neurons in embryonic cerebral cortical plate, sensory ganglia, and olfactory epithelium
Key result
Neuronal nitric oxide synthase displays transient, localized expression during early nervous system development.
Why the study?
Neuronal nitric oxide synthase is transiently expressed in discrete areas of the developing rat nervous system, but its developmental role is unclear.
Population
Developing rat nervous system at embryonic and early postnatal stages
Comparison
Transient NOS expression in cerebral cortical plate, sensory ganglia, and olfactory epithelium versus persistent expression in other neuronal sites
Design
Immunohistochemical and histochemical observational study
Authors
Discussion
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Member takes
Implication
No immediate clinical implications; leaves open nNOS roles in human neural development.
PICO
P
Population
Developing rat nervous system
E
Exposure / Comparator
Neuronal nitric oxide synthase (NOS) expression
O
Primary Outcome
Localization and timing of NOS expression
Cite This Study
Bredt et al. (1994) studied Developing rat nervous system. Neuronal nitric oxide synthase (NOS) expression was evaluated on Localization and timing of NOS expression. Neuronal nitric oxide synthase is transiently expressed in discrete areas of the developing rat nervous system, including the cerebral cortical plate, olfactory epithelium, and sensory ganglia.