Why the study?
Does traumatic injury induce neuronal nitric oxide synthase expression in spinal neurons?
Population
Animal model of traumatic spinal injury (ventral root avulsion and spinal cord transection)
Comparison
Traumatic injury vs Uninjured state (implied)
Design
Preclinical
Authors
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May not alter spinal trauma care; leaves open nNOS induction as a therapeutic target in humans.
Does traumatic injury induce neuronal nitric oxide synthase expression in spinal neurons?
Traumatic injury induces the expression of neuronal nitric oxide synthase in spinal neurons, challenging the notion that it is strictly constitutive.
Wu et al. (1994) studied this question.
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