Key result
Transfected TAR RNA attenuates human RNA interference by sequestering TRBP from downstream Dicer-RISC complexes.
Why the study?
The mechanism by which HIV-1 TAR RNA affects the RNA interference machinery in human cells was not fully understood.
HIV-1 TAR RNA subverts the host cell's RNA interference defense mechanism by sequestering the essential Dicer partner TRBP.
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Transfected TAR RNA attenuates RNAi via TRBP sequestration; leaves open its relevance to natural HIV infection or RNAi-based therapies.
Bennasser et al. (2006) studied HIV-1 / RNA interference. Transfected TAR RNA was evaluated on Attenuation of RNAi machinery / Inhibition of Dicer-RISC activity. Transfected TAR RNA attenuates the RNA interference machinery in human cells by sequestering TRBP, rendering it unavailable for downstream Dicer-RISC complexes.
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