What question did this study set out to answer?

To evaluate the efficacy and safety of a three-dose versus the standard two-dose regimen of intermittent preventive treatment with sulfadoxine-pyrimethamine for preventing placental malaria and low birth weight.

July 15, 2011Clinical Infectious DiseasesOpen Access

Superiority of 3 Over 2 Doses of Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine for the Prevention of Malaria During Pregnancy in Mali: A Randomized Controlled Trial

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Authors

KKKassoum KayentaoUniversity of Bamako BTBoubacar TraoréUniversity of Bamako ADAbdoulaye DjimdéUniversité de Perpignan

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Implication

Randomized superiority trial demonstrates that three doses of sulfadoxine-pyrimethamine cut placental malaria and low birth weight in pregnant women, indicating enhanced late-pregnancy protection.

Key Points

To evaluate the efficacy and safety of a three-dose versus the standard two-dose regimen of intermittent preventive treatment with sulfadoxine-pyrimethamine for preventing placental malaria and low birth weight.
Conducted a parallel-group, open-label, individually randomized controlled superiority trial (ISRCTN 74189211) in Mali involving 814 pregnant women of all gravidity enrolled from April 2006 through March 2008.
Participants received either 2 doses (n = 401) or 3 doses (n = 413) of sulfadoxine-pyrimethamine, with 96% followed through delivery to assess placental malaria, birth outcomes, maternal anemia, and adverse events.
Placental malaria prevalence was significantly lower in the 3-dose group at 8.0% compared with 16.7% in the 2-dose group (adjusted prevalence ratio [APR], 0.48; 95% CI, 0.32–0.71).
The 3-dose regimen reduced low birth weight (6.6% vs 13.3%; APR, 0.50; 95% CI, 0.32–0.79) and preterm births (3.2% vs 8.9%; APR, 0.37; 95% CI, 0.19–0.71).
No significant differences were detected between regimens for maternal anemia or safety endpoints, including severe maternal skin reactions and neonatal jaundice.

Cite This Study

Kayentao et al. (2011) studied this question.

synapsesocial.com/papers/6aaddb5e8ee7767afd873daa https://doi.org/10.1093/cid/cir374

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Implication

Randomized superiority trial demonstrates that three doses of sulfadoxine-pyrimethamine cut placental malaria and low birth weight in pregnant women, indicating enhanced late-pregnancy protection.

Superiority of 3 Over 2 Doses of Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine for the Prevention of Malaria During Pregnancy in Mali: A Randomized Controlled Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

Superiority of 3 Over 2 Doses of Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine for the Prevention of Malaria During Pregnancy in Mali: A Randomized Controlled Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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