New Treatments for Psoriasis

Psoriasis is an inflammatory skin disorder that affects about 1 to 3 percent of persons throughout the world.1 Although most persons with plaque psoriasis have mild or moderate disease that affects small areas of the skin, some have extensive disease that is severe and difficult to treat. It is not known why some persons have severe disease and others have mild involvement.One theory of the pathogenesis of psoriasis is that it is primarily a disorder that involves the proliferation of keratinocytes, with secondary inflammation. Supporters of this concept have noted defects in cytokine expression, intracellular signaling, and polyamines, as . . .