Key result
Astaxanthin lowers BP, delays stroke, and reduces coronary wall thickness in hypertensive rats.
Why the study?
Astaxanthin has shown various pharmacological activities including antihypertensive effects in animal models, but its mechanisms and antiatherogenic potential require further elucidation.
Does astaxanthin reduce blood pressure and prevent stroke in hypertensive rat models?
Does astaxanthin reduce blood pressure and prevent stroke in hypertensive rat models?
Preclinical evidence suggests astaxanthin has antihypertensive properties and may ameliorate hypertension-induced vascular remodeling.
Astaxanthin effects on blood pressure remain preclinical; leaves open any role in human hypertension pending trials.
Astaxanthin is a biological antioxidant naturally found in a wide variety of aquatic living organisms, and has shown various pharmacological activities, such as anti-inflammatory and antidiabetic activities. A recent study reported that the administration of astaxanthin induced a significant reduction in blood pressure and delayed the incidence of stroke in stroke-prone spontaneously hypertensive rats, suggesting that astaxanthin also has antihypertensive effect. In a study using aortic rings of spontaneously hypertensive rats, astaxanthin induced a significant reduction of the contractile responses of the aorta to α-adrenergic receptor agonist and angiotensin II, which may contribute to the antihypertensive effect of astaxanthin. In a histopathological study, astaxanthin decreased coronary artery wall thickness compared with the control, indicating the possibility that astaxanthin ameliorates hypertension-induced vascular remodeling. Astaxanthin has anti-inflammatory, antidiabetic, antihypertensive, and antioxidative activities; therefore, we should perform further studies to elucidate an antiatherogenic effect of astaxanthin.
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Hidekatsu Yanai (2008) conducted a review in Hypertension. Astaxanthin vs. control was evaluated. Astaxanthin administration in hypertensive rats reduced blood pressure, delayed stroke incidence, and decreased coronary artery wall thickness compared with control.
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