Key result
Influenza-associated encephalopathy incidence peaks in children but is linked to ~20% fatality in older adults.
Why the study?
Understanding of influenza-associated encephalopathy (IAE) among adults is limited compared to children, despite its severe neurologic impact and high mortality.
Population
385 influenza-associated encephalopathy cases in children and adults in Japan from 2010 through 2015
Comparison
Children versus adults with IAE
Design
Observational study using national surveillance data
Authors
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Adult IAE shows distinct features with higher fatality in older patients; leaves open optimal management strategies.
Observational (n=385)
Yes
Although influenza-associated encephalopathy is more common in children, mortality is significantly higher in affected adults.
Okuno et al. (2017) conducted an observational in Influenza-associated encephalopathy (n=385). Adult age (≥18 years) vs. Children (<18 years) was evaluated on Clinical characteristics and outcomes including case fatality proportion. Although influenza-associated encephalopathy incidence was higher in children, case fatality was highest in adults aged 40-64 (17%) and ≥65 (20%) years.
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