Key result
Higher preprocedural TG/HDL-C ratio is linked to ISR with a predictive cutoff of 3.8.
Why the study?
The impact of preprocedural TG/HDL-C ratio on the risk of in-stent restenosis after successful coronary stent implantation due to stable angina was unclear.
Is the preprocedural TG/HDL-C ratio associated with the risk of in-stent restenosis in patients undergoing coronary stent implantation for stable angina?
Cohort (n=1,341)
Is the preprocedural TG/HDL-C ratio associated with the risk of in-stent restenosis in patients undergoing coronary stent implantation for stable angina?
p-value: p=<.001
An elevated preprocedural TG/HDL-C ratio (cutoff 3.8) is independently associated with an increased risk of in-stent restenosis in patients undergoing stenting for stable angina.
May flag higher ISR risk via TG/HDL-C in stable angina stenting; leaves open prospective validation before clinical use.
We examined the impact of the preprocedural triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio on risk of in-stent restenosis (ISR). Patients with typical anginal symptoms and/or positive treadmill or myocardial perfusion scintigraphy test results who underwent successful coronary stent implantation due to stable angina were examined; 1341 patients were enrolled. The hospital files of the patients were used to gather data. Cox regression analysis showed that the TG/HDL-C ratio was independently associated with the presence of ISR ( P < .001). Moreover, diabetes mellitus ( P = .007), smaller stent diameter ( P = .046), and smoking status ( P = .001) were also independently associated with the presence of ISR. Using a cutoff of 3.8, the TG/HDL-C ratio predicted the presence of ISR with a sensitivity of 71% and a specificity of 68%. Also, the highest quartile of TG/HDL-C ratio had the highest rate of ISR ( P < .001). Measuring preprocedural TG/HDL-C ratio, in fasting or nonfasting samples, could be beneficial for the risk assessment of ISR. However, further large-scale prospective studies are required to establish the exact role of this simple, easily calculated, and reproducible parameter in the pathogenesis of ISR.
No takes yet. Share an insight, caveat, or question.
Kundi et al. (2017) conducted a cohort in Stable angina (n=1,341). Preprocedural TG/HDL-C ratio vs. Lower TG/HDL-C ratio was evaluated on In-stent restenosis (ISR) (p=<.001). A higher preprocedural TG/HDL-C ratio was independently associated with in-stent restenosis (P<.001), with a cutoff of 3.8 predicting ISR with 71% sensitivity and 68% specificity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: