Why the study?
The relationship between plasma matrix metalloproteinase-28 levels and GRACE scores as well as short-term prognosis in patients with acute myocardial infarction was unclear.
Are circulating MMP-28 levels associated with GRACE scores and short-term outcomes in patients with acute myocardial infarction?
Cohort (n=211)
Are circulating MMP-28 levels associated with GRACE scores and short-term outcomes in patients with acute myocardial infarction?
Elevated plasma MMP-28 levels in AMI patients correlate with higher GRACE scores and increased risk of short-term cardiovascular events and death.
MMP-28 may aid short-term risk stratification in AMI; hypothesis-generating and requires prospective validation before clinical adoption.
Objective. To investigate the relationship between the level of matrix metalloproteinase‐28 (MMP‐28) in patients with acute myocardial infarction (AMI) and the global registry of acute coronary events (GRACE) scores as well as their short‐term prognosis. Methods. Two hundred eleven patients with AMI were enrolled, and their basic clinical characteristics were collected for determining the GRACE score. We measured the plasma levels of MMP‐28 and other biomarkers in the study population. The association of MMP‐28 levels with cardiac events and cardiac deaths occurring within 30 days of discharge was evaluated with multivariable Cox proportional hazard models. Results. The MMP‐28 levels were significantly higher in patients with acute ST‐elevation myocardial infarction (STEMI) than in patients with non‐ST‐elevation myocardial infarction (NSTEMI) (P < 0.01). Correlation analysis showed that the level of MMP‐28 was positively correlated with the GRACE score in patients with AMI (R2 = 0.366, P < 0.05). Cox multivariate regression results showed that MMP‐28 was associated with cardiovascular events during the hospitalization and 30 days after discharge (P < 0.01). In addition, Kaplan–Meier analysis showed that cardiac events and deaths were significantly higher in patients with MMP‐28 ≥ 1.21 ng/mL (all P < 0.01). Conclusion. There is a correlation between the plasma MMP‐28 level and GRACE score in patients with AMI. MMP‐28 is also associated with cardiovascular events and cardiovascular deaths during the hospitalization of patients and within 30 days of discharge.
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Zhou et al. (2020) conducted a cohort in acute myocardial infarction (n=211). Plasma MMP-28 levels vs. Lower MMP-28 levels was evaluated on cardiovascular events and cardiovascular deaths during hospitalization and within 30 days of discharge (p=< 0.01).
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