Key result
Higher admission MMP-9 linked to ~5-fold higher in-hospital mortality after emergency PCI for AMI.
Why the study?
Does an elevated admission plasma MMP-9 level predict in-hospital mortality in AMI patients undergoing emergency PCI?
Cohort (n=155)
No
Does an elevated admission plasma MMP-9 level predict in-hospital mortality in AMI patients undergoing emergency PCI?
Answers are grounded in this paper and cite their sources.
Elevated admission plasma MMP-9 levels serve as an independent, early predictor of short-term in-hospital mortality in patients with AMI treated with emergency PCI.
// Jia-Jun Zhu 1, 2, * , Qian Zhao 1, 2, * , Hui-Juan Qu 1, 2 , Xiao-Mei Li 1, 2 , Qing-Jie Chen 1, 2 , Fen Liu 1, 2, 3 , Bang-Dang Chen 1, 2, 3 and Yi-Ning Yang 1, 3 1 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China 2 Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, China 3 Clinical Research Institute of Xinjiang Medical University, Urumqi, China * These authors have contributed equally to this work Correspondence to: Yi-Ning Yang, email: yangyn5126@163.com Keywords: MMP-9; STEMI; in-hospital mortality; coronary artery intervention Received: March 24, 2017 Accepted: September 21, 2017 Published: November 11, 2017 ABSTRACT The aim of the present study was to investigate the predictive value of the plasma matrix metalloproteinase-9 (MMP-9) level at admission for in-hospital mortality in patients who received emergency percutaneous coronary intervention (PCI) following AMI. A single blood sample was collected at admission from 155 consecutive AMI patients who underwent emergent PCI. The plasma levels of MMP-9 value (528.9±191.6 ng/ml) were significantly higher in the patients who died (n=24) than in the survivors (385.4±236.0 ng/ml) during 14 days of hospitalization ( P =0.005). The age, left ventricle wall motion score index (WMIS), Global Registry of Acute Coronary Events (GRACE) score and B-type natriuretic peptide (BNP) levels and GENSINI score at admission were significantly different between the patients who died and those who survived ( P <0.001, P =0.004, P <0.001 and P <0.001, respectively). Cut-off concentrations for prediction of death was identified from receiver operator characteristic (ROC) curves. Using the cut-off value (MMP-9 level 398.2 ng/ml) to stratify the patients into two groups, the group with higher MMP-9 levels had a greater rate of in-hospital mortality than the lower level group ( P <0.001). With the exception of the GRACE score, among all biomarkers measured, in stepwise multiple logistic regressions, only the MMP-9 level predicted the risk of in-hospital death after adjustment for all other risk factors (odds ratio 5.02, 95% CI 1.44 to 17.55). In conclusion, a higher MMP-9 level is an independent predictor of in-hospital death in AMI patients who received emergency PCI.
No takes yet. Share an insight, caveat, or question.
Zhu et al. (2017) conducted a cohort in Acute myocardial infarction (AMI) undergoing emergency PCI (n=155). Higher plasma MMP-9 level at admission vs. Lower plasma MMP-9 level at admission was evaluated on In-hospital mortality (OR 5.02, 95% CI 1.44-17.55, p=<0.001). Higher plasma MMP-9 level at admission independently predicted an increased risk of in-hospital death (OR 5.02) in AMI patients undergoing emergency PCI.
Synapse has enriched 10 related papers. Consider them for comparative context: