Immunization of patients with chronic renal insufficiency with plasma from selected donors elicited lymphocytotoxic antibodies. Analysis of these antibodies with Fab2 blocking assays showed that they are directed to HLA-A,B and to Ia-like antigens. These results indicate that serum HLA antigens are immunogenic in allogeneic combinations.
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Pellegrino et al. (1982) studied this question.