Key result
Serum GDF-15 levels are linked to aortic stiffness in newly diagnosed essential hypertension.
Why the study?
The relationship between serum growth differentiation factor-15 and echocardiographic parameters of aortic elasticity in newly diagnosed essential hypertension was not well established.
Is serum GDF-15 associated with echocardiographic parameters of aortic stiffness in patients with newly diagnosed essential hypertension?
Observational (n=155)
Is serum GDF-15 associated with echocardiographic parameters of aortic stiffness in patients with newly diagnosed essential hypertension?
Serum GDF-15 levels are independently associated with echocardiographic markers of aortic stiffness in patients with essential hypertension, suggesting its potential utility as a biomarker for vascular compliance.
GDF-15 may mark aortic stiffness in new hypertension; hypothesis-generating from cross-sectional data and requires prospective validation.
AIM: We aimed to assess the relationship between echocardiographic parameters of aortic elasticity, namely aortic strain, aortic distensibility and aortic β-index, and serum growth differentiation factor (GDF)-15 in patients with newly diagnosed essential hypertension (HT). METHODS: Grade-1 HT patients (n = 50), grade-2 HT (n = 70) patients and 35 healthy controls were included. RESULTS: GDF-15 was greater in grade-2 HT group compared with the other groups. All aortic elasticity parameters were worse in grade-2 HT group compared with the other groups. GDF-15 correlated positively with E/E' ratio (the ratio of transmitral E velocity to mean diastolic mitral annular velocity) and β-index; and aortic strain and aortic distensibility correlated negatively with serum GDF-15. β-index, aortic diastolic diameter and diastolic blood pressure were independently associated with GDF-15. CONCLUSION: GDF-15 may be utilized in the prediction of increased aortic stiffness.
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Sökmen et al. (2019) conducted an observational in Essential hypertension (n=155). Serum GDF-15 levels was evaluated on Relationship between echocardiographic parameters of aortic elasticity and serum GDF-15. Serum GDF-15 levels were independently associated with aortic stiffness parameters, including beta-index and aortic diastolic diameter, in patients with newly diagnosed essential hypertension.
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