What question did this study set out to answer?

To isolate and characterize new sulfur-containing phenolic metabolites from cave soil-derived Aspergillus fumigatus GZWMJZ-152 and evaluate their antioxidant activities.

February 2, 2022Journal of Natural Products

Sulfur-Containing Phenolic Compounds from the Cave Soil-Derived Aspergillus fumigatus GZWMJZ-152

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Authors

YXYanchao XuZhejiang Normal University WLWen LiuChinese Academy of Sciences DWDan WuJilin Agricultural University

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Implication

In vitro study uncovers novel sulfur-containing phenolics from Aspergillus fumigatus with antioxidant activity in PC12 cells, highlighting their protective capacity against oxidative stress.

Key Points

To isolate and characterize new sulfur-containing phenolic metabolites from cave soil-derived Aspergillus fumigatus GZWMJZ-152 and evaluate their antioxidant activities.
Purified compounds 1–9 and elucidated their chemical structures and absolute configurations via spectroscopic analysis, X-ray diffraction, and electronic circular dichroism calculations.
Assessed antioxidant properties using DPPH radical-scavenging assays, oxygen radical absorbance capacity (ORAC) assays, and cytoprotection assays against H2O2-induced oxidative injury in PC12 cells.
Compounds 5, 6, 7, and 9 demonstrated DPPH free radical-scavenging activity with IC50 values of 3.45 ± 0.02, 23.73 ± 0.08, 18.90 ± 0.16, and 17.27 ± 0.15 μM, respectively.
Compounds (±)-2, 4, 7, and 8 displayed marked antioxidant capacity in ORAC assays with values of 1.73 ± 0.13, 1.65 ± 0.03, 6.14 ± 0.35, and 1.55 ± 0.04 μmol TE/μmol, while (±)-2 and (±)-3 protected PC12 cells against H2O2 damage.

Cite This Study

Xu et al. (2022) studied this question.

synapsesocial.com/papers/6aadec46322a2d038800e129 https://doi.org/10.1021/acs.jnatprod.1c01158

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Implication

In vitro study uncovers novel sulfur-containing phenolics from Aspergillus fumigatus with antioxidant activity in PC12 cells, highlighting their protective capacity against oxidative stress.

Sulfur-Containing Phenolic Compounds from the Cave Soil-Derived Aspergillus fumigatus GZWMJZ-152

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Implication

Key Points

Cite This Study

Sulfur-Containing Phenolic Compounds from the Cave Soil-Derived Aspergillus fumigatus GZWMJZ-152

Discussion

Member takes

Implication

Key Points

Cite This Study

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