What question did this study set out to answer?

To determine how HIV-1 infection of CD4 T cells impairs antigen-specific B-cell functions and inhibits the production of neutralizing antibodies.

November 4, 2020The EMBO JournalOpen Access

HIV‐1 infection of CD4 T cells impairs antigen‐specific B cell function

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Authors

SKSheetal KawHeidelberg University SASwetha AnanthHeidelberg University NTNikolaos TsopoulidisHarvard University

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Implication

Experimental study reveals that HIV-1 NEF disrupts CD4 T-cell help to impair antigen-specific B-cell responses, suggesting a target to restore antibody production.

Key Points

To determine how HIV-1 infection of CD4 T cells impairs antigen-specific B-cell functions and inhibits the production of neutralizing antibodies.
Assessed T-cell helper activity and cognate B-cell responses using an adoptive transfer mouse model.
Modeled viral pathogenesis using ex vivo HIV-1 infection of human tonsil tissue expressing the viral NEF protein.
HIV-1 NEF expression in CD4 T cells utilized a specific protein interaction motif to block polarized cytokine secretion at the T-cell–B-cell immune synapse.
Loss of polarized signaling reduced B-cell activation and proliferation, which disrupted germinal center formation, affinity maturation, and specific IgG production.

Cite This Study

Kaw et al. (2020) studied this question.

synapsesocial.com/papers/6aadedabc150ecefac183696 https://doi.org/10.15252/embj.2020105594

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Implication

Experimental study reveals that HIV-1 NEF disrupts CD4 T-cell help to impair antigen-specific B-cell responses, suggesting a target to restore antibody production.

HIV‐1 infection of CD4 T cells impairs antigen‐specific B cell function

Discussion

Member takes

Implication

Key Points

Cite This Study

HIV‐1 infection of CD4 T cells impairs antigen‐specific B cell function

Discussion

Member takes

Implication

Key Points

Cite This Study

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