NF2 and ZFTA evaluation in the diagnostic algorithm of pediatric posterior fossa ependymoma with H3K27ME3 retained expression

Arnault Tauziède‐Espariat; Yassine Ajlil; Marie-Anne Debily; David Castel; Jacques Grill; Stéphanie Puget; Lauren Hasty; Fabrice Chrétien; Alice Métais; Volodia Dangouloff‐Ros; Nathalie Boddaert; Pascale Varlet

doi:10.1186/s40478-023-01503-2

January 13, 2023Acta Neuropathologica CommunicationsOpen Access

NF2 and ZFTA evaluation in the diagnostic algorithm of pediatric posterior fossa ependymoma with H3K27ME3 retained expression

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Abstract

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Posterior fossa ependymomas can be subdivided into two types based on molecular profiling: A (PFA) and B (PFB) [4]. Immunophenotypically, they differ in the expression of H3K27me3: PFA show loss of this mark while PFB retain its expression. Furthermore, they

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Tauziède‐Espariat et al. (2023) studied this question.

synapsesocial.com/papers/6aadee7aad4280f693b8b0b3 https://doi.org/10.1186/s40478-023-01503-2

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NF2 and ZFTA evaluation in the diagnostic algorithm of pediatric posterior fossa ependymoma with H3K27ME3 retained expression

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NF2 and ZFTA evaluation in the diagnostic algorithm of pediatric posterior fossa ependymoma with H3K27ME3 retained expression

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