Key result
Low-dose tibolone induces similar brachial artery flux changes as conventional doses in postmenopausal women.
Why the study?
The comparative effects of low versus conventional doses of tibolone on brachial artery vascular responses in postmenopausal women were not established.
Does low-dose tibolone compared to conventional-dose tibolone induce similar changes in brachial artery flux parameters in postmenopausal women?
RCT (n=24)
Alternately assigned
No
Does low-dose tibolone compared to conventional-dose tibolone induce similar changes in brachial artery flux parameters in postmenopausal women?
Low and conventional doses of tibolone induce similar changes in brachial artery vascular responses in postmenopausal women.
May support lower tibolone dosing to limit exposure in postmenopausal women; hypothesis-generating and requires randomized outcome trials.
OBJECTIVE: To compare the effects of low and conventional doses of tibolone in brachial artery flux parameters among postmenopausal women. METHODS: Between March 2011 and September 2012, 24 postmenopausal women attending Gynecology and Obstetrics Hospital Luis Castelazo Ayala, Mexico City, for hormone replacement therapy were consecutively recruited. The women were alternately assigned to receive a daily dose of either 2.5mg (n=11) or 1.25mg (n=13) of oral tibolone. Before and after treatment, all women underwent a brachial artery Doppler ultrasound. The arterial diameter was measured, and the pulsatility index (PI) and the resistance index (RI) were calculated. A hyperemic stimulus was then induced and these parameters were measured again. RESULTS: Among the 24 women, the time since menopause ranged from 16 to 24 months, and the median treatment duration was 3 months. Both groups showed a significant increase in arterial diameter after treatment. There was no significant difference between the groups in arterial diameter, PI, and RI. The arterial diameter after hyperemic stimulus was significantly lower after treatment than before treatment in both groups. CONCLUSION: Low and conventional doses of tibolone induced similar changes in brachial artery flux parameters among postmenopausal women.
No takes yet. Share an insight, caveat, or question.
Carranza‐Lira et al. (2013) conducted an RCT in Postmenopausal requiring hormone replacement therapy (n=24). Tibolone vs. 1.25 mg daily was evaluated on Brachial artery flux parameters (arterial diameter, pulsatility index, and resistance index). Low (1.25 mg) and conventional (2.5 mg) daily doses of oral tibolone induced similar changes in brachial artery flux parameters among postmenopausal women.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: