Why the study?
Does tibolone 2.5 mg per day improve brachial artery responses to hyperemic stimuli in postmenopausal women?
Does tibolone 2.5 mg per day improve brachial artery responses to hyperemic stimuli in postmenopausal women?
Tibolone treatment for 6 months favorably affects brachial artery responses to hyperemic stimuli in postmenopausal women, suggesting a potential improvement in endothelial function.
May indicate endothelial benefit from tibolone; hypothesis-generating and requires randomized confirmation before practice change.
OBJECTIVE: To determine the effect of tibolone treatment on brachial artery pulsatility index (PI), resistance index (RI), and flux-mediated dilation (FMD) in postmenopausal Mexican women. METHOD: The FMD, PI, and RI of the right brachial artery were measured in 19 postmenopausal women before and after they received a hyperemic stimulus, first at baseline and then following a 6-month treatment with 2.5 mg of tibolone per day. Statistical analysis was performed using the t test. RESULTS: The mean+/-SD age was 52.2+/-3.9 years; time since menopause was 24.6+/-16.7 months; and treatment duration was 5.7+/-2.0 months. Compared with prestimulus measurements, a significant poststimulus increase in arterial diameter and a significant decrease in PI were observed at baseline. Compared with prestimulus measurements, a significant poststimulus increase in arterial diameter and a significant decrease in both PI and RI were observed post-treatment. CONCLUSION: Tibolone treatment had a favorable effect on brachial artery responses to hyperemic stimuli.
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Carranza‐Lira et al. (2007) studied this question.
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