Why the study?
Does tibolone improve lipid profiles and counteract early carotid atherosclerotic lesions in postmenopausal women?
Does tibolone improve lipid profiles and counteract early carotid atherosclerotic lesions in postmenopausal women?
A 6-month treatment with tibolone may improve lipid profiles and halt the progression of carotid intima-media thickness in postmenopausal women.
Tibolone may improve lipids and stabilize carotid IMT in postmenopausal women; extends RCT evidence on its vascular effects.
OBJECTIVE: To study whether tibolone affects lipid profile and diffused intima media thickness (IMT) of the common carotid arteries (CCA) in postmenopausal women (PMW). METHODS: Twenty-two PMW and 20 premenopausal women participated in the study. The PMW were randomly divided into 11 women who did not receive any treatment and 11 women who received tibolone (2.5 mg once a day). RESULTS: After 6 months the treated women had lipoprotein(a) (Lpa), total-cholesterol (total-C), and LDL-cholesterol (LDL-C) levels lower than before, while in the non-treated women Lpa was increased. The IMT of CCA was unmodified in the treated women, whereas it increased in non-treated women. CONCLUSIONS: This preliminary study suggests that a 6-month tibolone treatment could counteract the increase of the IMT of CCA observed in untreated PMW.
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Anedda et al. (2003) studied this question.
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