Key result
CXCR4/SDF-1 axis manipulation may improve MSC homing and efficacy in acute MI.
Why the study?
Inefficient migration and homing of mesenchymal stem cells have limited their therapeutic applications in acute myocardial infarction, motivating exploration of the CXCR4/SDF-1 axis to improve cell therapy.
The CXCR4/SDF-1 axis represents a promising therapeutic target to improve the migration and homing of mesenchymal stem cells for the treatment of acute myocardial infarction.
Should not yet change AMI stem cell therapy; leaves open the need for randomized trials of CXCR4/SDF-1 modulation.
Acute Myocardial Infarction (AMI) is one of the mortal diseases which relate to heart and has many impacts on patients’ life. Stem cell therapy, including mesenchymal stem cells (MSCs), has emerged a promise treatment for patients with this disease. However, the inefficient migration and homing of MSCs have limited their therapeutic applications. It has been demonstrated that CXCR4/SDF-1 axis has a crucial role in cell migration and stem cell homing. So, many studies have conducted and currently are operating by novel methods to improve homing of MSCs by up-regulating the expression of CXCR4/SDF-1 axis to discover a proper cell therapy for AMI. CXCR4/SDF-1 axis triggers a variety of biological responses, such as directing cell migration, organogenesis, hematopoiesis, vascularization, and immune responses. Therefore, this axis might be a good candidate for manipulation with therapeutic purposes.
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Toosi et al. (2017) conducted a review in Acute Myocardial Infarction. CXCR4/SDF-1 axis manipulation was evaluated. Manipulation of the CXCR4/SDF-1 axis may improve the homing and therapeutic efficacy of mesenchymal stem cells in acute myocardial infarction.
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