Key result
Hibernating myocardium in CAD shows structural damage and MMP9 accumulation indicating lost future contractile function.
Why the study?
There is uncertainty about the timing and completeness of restoration of myocardial dysfunction areas in ischemic myocardium of patients with chronic coronary artery disease.
Observational (n=25)
Hibernating myocardium in CAD patients exhibits structural destruction of sarcomeres and basement membranes, suggesting it may be unable to recover contractile function after revascularization.
Answers are grounded in this paper and cite their sources.
May limit post-revascularization recovery in hibernating myocardium; hypothesis-generating for MMP9-targeted interventions in CAD.
Introduction.Currently, there are different approaches to assessing changes that occur in ischemic myocardium in patients with chronic coronary artery disease (CAD). Researchers argue about the timing and completeness of the restoration of myocardial dysfunction areas. We aimed to assess hibernating myocardium in the zones of hypokinesia in patients with CAD. Materials and methods. We performed a morphological and immunohistochemical study of left ventricular myocardial biopsies of 25 patients who underwent surgical reconstruction of the left ventricle with surgical revascularization. Results. Morphological and immunohistochemical studies revealed violated morphological structure of cardiomyocytes. It correlates with the accumulation of MMP9 in the cytoplasm of cardiomyocytes in the areas of affected myocardium in ischemia against the background of partial or complete destruction of CM basement membranes formed by type IV collagen. It also correlates with long-term consequences of treatment. Conclusion. As a result of the destructed structure of sarcomeres and cardiac basement membrane hibernating myocardium is unable to provide a contractile function in the future. Morphological examination showed that viable cells were likely to function only as a protective mechanism in early scar formation.
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Popov et al. (2023) conducted an observational in chronic coronary artery disease (CAD) (n=25). Hibernating myocardium was evaluated on Morphological structure of cardiomyocytes and accumulation of MMP9. In patients with CAD, hibernating myocardium showed violated cardiomyocyte structure and MMP9 accumulation, indicating an inability to provide future contractile function.
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