Key result
Female sex linked to ~211% greater Takotsubo cardiomyopathy risk in non-traumatic subarachnoid hemorrhage.
Why the study?
There is a scarcity of literature describing the prevalence and risk factors associated with Takotsubo Cardiomyopathy after non-traumatic subarachnoid hemorrhage.
Population
42,141 adult inpatients with non-traumatic subarachnoid hemorrhage from 2016 to 2021 National Inpatient Sample
Comparison
Patients with Takotsubo Cardiomyopathy vs patients without Takotsubo Cardiomyopathy
Design
Observational cohort study using National Inpatient Sample data
Follow-up
In-hospital
Authors
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May warrant closer monitoring in female SAH patients; leaves open whether targeted strategies reduce incidence.
Observational (n=42,141)
Yes
Odds Ratio: 3.11 (95% CI 2.5–3.89)
p-value: p=<.001
Takotsubo cardiomyopathy is a rare but severe complication of non-traumatic subarachnoid hemorrhage, occurring more frequently in females and those with pre-existing heart failure, and is associated with significantly higher in-hospital mortality and resource utilization.
Pando et al. (2025) conducted an observational in Non-traumatic subarachnoid hemorrhage (n=42,141). Female sex vs. Male sex was evaluated on Takotsubo Cardiomyopathy (TCM) (OR 3.11, 95% CI 2.50-3.89, p=<.001). Female sex was an independent risk factor for developing Takotsubo cardiomyopathy in patients with non-traumatic subarachnoid hemorrhage (OR 3.11; 95% CI 2.50-3.89; P<0.001).
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