November 16, 2016European Heart Journal Acute Cardiovascular Care
Clinical presentations and outcomes of Takotsubo syndrome in the setting of subarachnoid hemorrhage: A systematic review and meta-analysis
Key result
In patients with spontaneous subarachnoid hemorrhage, concomitant Takotsubo syndrome was associated with significantly increased odds of in-hospital mortality (OR 2.6; 95% CI 1.16-5.85; p=0.02).
Why the study?
Does the development of Takotsubo syndrome increase in-hospital mortality in patients with spontaneous subarachnoid hemorrhage?
Population
10 studies with a total of 157 patients presenting with classical Takotsubo syndrome on transthoracic…
Comparison
Concomitant classical Takotsubo syndrome vs Subarachnoid hemorrhage without Takotsubo syndrome
Design
Meta-analysis
Follow-up
in-hospital
Authors
Discussion
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Implication
Alerts clinicians to higher in-hospital mortality in SAH with Takotsubo; confirms association and supports prognostic stratification.
Study Design
Type
Meta-Analysis (n=157)
Structured PICO
Does the development of Takotsubo syndrome increase in-hospital mortality in patients with spontaneous subarachnoid hemorrhage?
P
Population
10 studies including 157 patients with spontaneous subarachnoid hemorrhage and concomitant classical Takotsubo syndrome.
E
Exposure
Concomitant classical Takotsubo syndrome
C
Comparator
Subarachnoid hemorrhage without Takotsubo syndrome
O
Outcome
In-hospital mortalityhard clinical
Main Result
Odds Ratio: 2.6 (95% CI 1.16–5.85)
p-value: p=0.02
The development of Takotsubo syndrome in patients with spontaneous subarachnoid hemorrhage is associated with a significantly increased risk of in-hospital mortality.
Cite This Study
Elgendy et al. (2016) conducted a meta-analysis in Takotsubo syndrome in the setting of subarachnoid hemorrhage (n=157). Takotsubo syndrome vs. No Takotsubo syndrome was evaluated on in-hospital mortality (OR 2.6, 95% CI 1.16-5.85, p=0.02). In patients with spontaneous subarachnoid hemorrhage, concomitant Takotsubo syndrome was associated with significantly increased odds of in-hospital mortality (OR 2.6; 95% CI 1.16-5.85; p=0.02).