Key result
Cardiovascular autonomic neuropathy affects ~60% of Egyptian T2D patients, correlating with HbA1c and total cholesterol.
Why the study?
Cardiovascular autonomic neuropathy is a common underdiagnosed complication of diabetes, and its prevalence in Egyptian people with type 2 diabetes was not well established.
Cross-Sectional (n=120)
Cardiovascular autonomic neuropathy is highly prevalent (60%) among Egyptian patients with type 2 diabetes and is significantly correlated with HbA1c and total cholesterol.
High CAN prevalence supports screening consideration in Egyptian T2DM; leaves open whether HbA1c or cholesterol control alters risk.
Background Diabetes is a metabolic disorder characterized by chronic hyperglycemia and has long standing complication including both micro and macro vascular ones. One of the common underdiagnosed complications of diabetes is cardiovascular autonomic neuropathy (CAN), which encompasses damage to the autonomic nerve fiber that innervates the heart and blood vessels. Objective The aim of this work was to assess the prevalence of CAN in Egyptian people with type 2 diabetes. Patients and Methods The study was conducted on 120 subjects with type 2 diabetes. CAN was assessed by a group of defined cardiovascular autonomic reflex tests including (Resting heart rate, Heart rate response to standing, Beat-to-beat HRV, Blood pressure response to standing, Diastolic blood pressure response to isometric exercise and QTc interval). Patients with CAN were subsequently divided into three groups, Early, Definite and severe CAN. Results and Conclusion The prevalence of CAN is high in Egyptian people with type 2 diabetes amounting to 60%. Percentage of patients that had early, definite and severe CAN was 15%, 36.7% and 8.3% respectively. Positive significant independent correlation was found between CAN, HbA1c and serum total cholesterol.
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Rohoma et al. (2018) conducted a cross-sectional in Type 2 diabetes mellitus (n=120). Type 2 diabetes mellitus was evaluated on Prevalence of cardiovascular autonomic neuropathy (CAN). Cardiovascular autonomic neuropathy was present in 60% of Egyptian patients with type 2 diabetes, and was significantly correlated with HbA1c and serum total cholesterol.
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