Key result
A single dose of amitriptyline prolonged both QRS and QTc intervals and was highly proarrhythmogenic, while citalopram and venlafaxine prolonged only the QTc interval during ischemic-reperfusion injury.
Why the study?
The effects of amitriptyline, citalopram, and venlafaxine on cardiac electrical activity during ischemic-reperfusion injury were not well characterized.
Do amitriptyline, citalopram, and venlafaxine alter cardiac electrical activity and arrhythmogenicity during ischemic-reperfusion injury?
Do amitriptyline, citalopram, and venlafaxine alter cardiac electrical activity and arrhythmogenicity during ischemic-reperfusion injury?
Antidepressants such as amitriptyline, citalopram, and venlafaxine alter cardiac electrical activity and increase the risk of dysrhythmias during ischemia-reperfusion injury.
May warrant caution in ischemia-reperfusion settings; leaves open human translation of these animal findings.
The aim of our work was to investigate the effect of amitriptyline, citalopram and venlafaxine on the heart during ischemic- reperfusion (l-R) injury. Amitriptyline prolonged both QRS complex and QTc interval duration; citalopram and venlafaxine prolonged only QTc interval duration. Amitriptyline worked most proarrhythmogenic, citalopram least; venlafaxine increased the heart rate during ischemia; however, prolonged QTc interval at the beginning of reperfusion was followed by serious dysrhythmias.
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Vicen et al. (2016) studied Ischemic-reperfusion myocardial injury (n=30). Antidepressants (amitriptyline, citalopram, venlafaxine) vs. Vehicle (I-R control) was evaluated on Changes in electrical activity (QTc interval and QRS complex duration) (p=≤0.05). A single dose of amitriptyline prolonged both QRS and QTc intervals and was highly proarrhythmogenic, while citalopram and venlafaxine prolonged only the QTc interval during ischemic-reperfusion injury.
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