Key result
Hyperglycemia blunts erythromycin-induced stimulation of antral wave frequency and amplitude versus euglycemia.
Why the study?
The gastrokinetic effects of erythromycin are attenuated by hyperglycemia, but its impact on antropyloroduodenal motility and antral pressure wave organization under hyperglycemia was unclear.
Does hyperglycemia attenuate the stimulation of antral motility by erythromycin in healthy male volunteers?
Comparison
Erythromycin during hyperglycemia (blood glucose ~15 mmol/L) vs erythromycin during euglycemia (blood glucose ~5 mmol/L)
Design
Randomized crossover study with manometric measurements
Follow-up
80 minutes
Authors
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Hyperglycemia may blunt erythromycin's antral prokinetic effects in gastroparesis; leaves open whether tight glycemic control augments its utility.
RCT (n=8)
Randomized order
Does hyperglycemia attenuate the stimulation of antral motility by erythromycin in healthy male volunteers?
p-value: p=<0.05
Hyperglycemia attenuates the prokinetic effects of erythromycin on antral motility, suggesting that blood glucose control may be important when using erythromycin for diabetic gastroparesis.
Rayner et al. (2000) conducted an RCT in Healthy volunteers (n=8). Erythromycin during hyperglycemia vs. Erythromycin during euglycemia was evaluated on Frequency and amplitude of antral waves (p=<0.05). Hyperglycemia significantly attenuated the erythromycin-induced stimulation of antral wave frequency (p<0.05) and amplitude (p<0.01) compared to euglycemia.
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