Key result
Early-stage Chagas cardiomyopathy is linked to ~40% lower absolute VO₂ at the anaerobic threshold vs controls.
Why the study?
Chagas cardiomyopathy is a silent and progressive disease in early stages, and its impact on functional capacity and quality of life is crucial to identify for safe rehabilitation inclusion.
Does early-stage Chagas cardiomyopathy (stages B1/B2) reduce functional capacity during cardiopulmonary exercise testing compared to matched controls?
Case-Control (n=28)
Does early-stage Chagas cardiomyopathy (stages B1/B2) reduce functional capacity during cardiopulmonary exercise testing compared to matched controls?
Absolute Event Rate: 0.6% vs 1%
p-value: p=<0.05
Patients with early-stage Chagas cardiomyopathy exhibit significantly impaired functional capacity during exercise testing compared to matched controls.
Hypothesis-generating for early functional impairment in Chagas cardiomyopathy; prospective studies needed before clinical adoption.
Introduction: Chagas cardiomyopathy (CC) may reduce cardiac hemodynamic performance, leading to decreased functional capacity (FC). As CC is a silent and progressive disease in its early stages, identifying its impact on functionality and quality of life is crucial for safe rehabilitation program inclusion. Objective: To assess the FC of individuals with CC stages B1/B2 during cardiopulmonary exercise testing (CPET). Methods: Fourteen CC patients (mean age: 64.7 ± 11.7 years, 57% male) and 14 age- and sex-matched controls underwent CPET on a cycle ergometer until exhaustion. Results: The CC group showed significantly lower absolute VO₂ (0.6±0.2 vs. 1.0±0.2 mL/min) and relative VO₂ (8.0±1.7 vs. 11.0±2.2 mL/kg/min) at the anaerobic threshold. At peak CPET, absolute VO₂, relative VO₂, and workload were also lower in the CC group (p<0.05). Conclusion: Individuals with CC stages B1/B2 exhibit impaired FC during CPET.
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Travassos et al. (2025) conducted a case-control in Chagas cardiomyopathy (n=28). Chagas cardiomyopathy stages B1/B2 vs. Age- and sex-matched controls was evaluated on Absolute VO₂ at the anaerobic threshold (mL/min) (p=<0.05). Early-stage Chagas cardiomyopathy was associated with significantly lower absolute VO₂ at the anaerobic threshold compared to matched controls (0.6 vs. 1.0 mL/min).
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