Key result
Low torque teno virus burden predicts acute rejection and tracks immunosuppression intensity after liver transplantation.
Why the study?
The pathogenicity of torque teno virus in liver diseases is controversial and its role as a biomarker after liver transplantation requires further evaluation in prospective trials.
Does Torque teno virus (TTV) viral load monitoring predict acute rejection episodes and reflect immunosuppression intensity in liver transplant recipients?
Population
Patients with liver diseases and liver transplant recipients
Comparison
TTV viral load as a biomarker versus standard immune monitoring
Design
Review
Authors
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May support TTV monitoring to gauge post-liver transplant immunosuppression intensity; leaves open whether it improves rejection outcomes in prospective studies.
Does Torque teno virus (TTV) viral load monitoring predict acute rejection episodes and reflect immunosuppression intensity in liver transplant recipients?
Torque teno virus viral load is a promising surrogate biomarker for monitoring immunosuppression intensity and predicting acute rejection in liver transplant recipients.
Mrzljak et al. (2020) conducted a review in Liver diseases and liver transplantation. Torque teno virus (TTV) viral load was evaluated. Torque teno virus viral load positively correlates with immunosuppression intensity after liver transplantation, with low viral burden predicting acute rejection episodes.
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