Key result
Parvovirus B19 in children can trigger fatal fulminant myocarditis driven by T-cell mediated inflammation.
Why the study?
Fulminant parvovirus B19 myocarditis in children and its underlying inflammatory mechanisms leading to fatal outcomes are not well understood.
Parvovirus B19 infection can trigger a fatal, predominantly T-cell mediated fulminant myocarditis in previously healthy children.
Raises caution for fatal T-cell myocarditis after parvovirus B19 in children; leaves open mechanisms pending larger studies.
We report 2 cases of previously healthy children, who developed, after a common parvovirus B19 infection, a sudden inflammatory response, involving predominantly T cell, directed against myocardium and leading to fatal outcome. These cases and several published case reports further our understanding of fulminating parvovirus myocarditis in children.
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Koehl et al. (2011) studied this question. Parvovirus B19 infection in children can trigger a sudden, predominantly T-cell mediated inflammatory response against the myocardium, leading to fatal fulminant myocarditis.
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