Key result
Fructose infusion improves work duration at lower concentrations than glucose in a muscle deficiency patient.
Why the study?
The effect of infused fructose on work capacity in a patient with a metabolic deficiency impairing glycogen utilization and lactic acid formation was investigated.
Does infused fructose improve work capacity in a patient with a metabolic deficiency of striated muscle?
Case Report (n=1)
Does infused fructose improve work capacity in a patient with a metabolic deficiency of striated muscle?
Fructose can traverse the muscle cell membrane and serve as fuel for muscular work in a patient with a glycogen utilization defect.
May support fructose as alternative fuel in rare striated muscle defects; hypothesis-generating and requires confirmation before clinical consideration.
Observations were made upon the effect of infused fructose on work capacity of a young male subject with an unusual metabolic deficiency of striated muscle in which there was a failure to form lactic acid under anaerobic conditions. The defect was tentatively ascribed to inability to utilize glycogen and was manifested clinically by limited exercise tolerance. 2. Duration of work was greatly improved by infusion of glucose or fructose. Fructose was effective at much lower plasma concentration than glucose. Therefore, fructose can traverse the muscle cell membrane and contribute significantly toward the fuel for muscular work in this patient.
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Pearson et al. (1959) conducted a case report in Metabolic deficiency of striated muscle (n=1). Infused fructose vs. Infused glucose was evaluated on Duration of work. Infusion of fructose greatly improved the duration of work in a patient with a metabolic deficiency of striated muscle, and was effective at a much lower plasma concentration than glucose.
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