Key result
A redesigned order set with decision support cuts nonindicated inpatient IV hydralazine use by ~64%.
Why the study?
Intravenous antihypertensives are often given for asymptomatic blood pressure elevations in hospitalized patients, leading to adverse events without improving outcomes.
Does a redesigned order set with decision support and education reduce the nonindicated use of IV hydralazine in hospitalized patients?
Does a redesigned order set with decision support and education reduce the nonindicated use of IV hydralazine in hospitalized patients?
Absolute Event Rate: 25% vs 69%
Embedding decision support in electronic order sets combined with targeted education significantly reduces the inappropriate inpatient use of IV hydralazine for asymptomatic blood pressure elevations.
BACKGROUND: Elevated blood pressure (BP) affects up to 72% of hospitalized patients. Intravenous (IV) antihypertensives are indicated for hypertensive emergencies, but they are often given for asymptomatic BP elevations, leading to hypotension, acute kidney injury, and intensive care unit transfers without improving outcomes. PROJECT RATIONALE: At UConn John Dempsey Hospital, 69% of IV hydralazine use between June 2023 and January 2024 lacked appropriate indications. PROJECT SUMMARY: A redesigned order set required prescribers to select a guideline-supported indication before ordering hydralazine. The order also displayed the last 5 BPs and included hyperlinks to American Heart Association guidelines. Education sessions for residents and nurses reinforced best practices and provided alternatives for asymptomatic BP elevations. TAKE-HOME MESSAGES: Nonindicated IV hydralazine use decreased from 69% to 25%. Order set modifications had a greater impact than education alone. Embedding decision support with targeted education offers a scalable, reproducible model for safer inpatient prescribing.
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Kumar et al. (2025) studied Inpatient asymptomatic blood pressure elevations. Redesigned order set with decision support and education vs. Baseline practice was evaluated on Nonindicated IV hydralazine use. A redesigned order set with embedded decision support and targeted education decreased nonindicated inpatient IV hydralazine use from 69% to 25%.
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