Key result
Adiponectin SNP45 TG/GG genotype linked to ~236% higher mtDNA somatic mutation rate versus TT genotype.
Why the study?
The correlation between adiponectin gene SNP45 T/G and long-term oxidative stress in T2DM patients with carotid atherosclerosis was unclear.
Is the adiponectin gene SNP45 T/G polymorphism associated with long-term oxidative stress (mtDNA mutation rates) in T2DM patients with carotid atherosclerosis?
Cross-Sectional (n=396)
No
Is the adiponectin gene SNP45 T/G polymorphism associated with long-term oxidative stress (mtDNA mutation rates) in T2DM patients with carotid atherosclerosis?
The adiponectin gene SNP45 T/G polymorphism is associated with increased mtDNA A3243A/G somatic mutation rates, suggesting a link between this genetic variant and oxidative stress in diabetic carotid atherosclerosis.
Hypothesis-generating for oxidative stress role of adiponectin SNP45 in diabetic atherosclerosis; prospective studies needed before clinical consideration.
The aim of the present study was to investigate the correlation between the adiponectin gene single nucleotide polymorphism (SNP)45 T/G and long‑term oxidative stress in type II diabetes mellitus (T2DM) patients with carotid atherosclerosis. Patients with T2DM were divided into non‑carotid atherosclerosis and carotid atherosclerosis groups, which were then subsequently divided into TT and TG + GG groups according to the adiponectin SNP45 T/G genotypes. Enzyme‑linked immunosorbent assay, TaqMan probe quantitative polymerase chain reaction (PCR), PCR‑TaqMan, color Doppler and other methods were used to determine the adiponectin levels, gene polymorphisms, acquired mitochondrial DNA (mtDNA) A3243G somatic cell mutation rates and the carotid intima‑media thickness. The somatic cell mutation rate of acquired mtDNA A3243A/G in the T2DM carotid atherosclerosis group was significantly higher compared with the group without carotid atherosclerosis. In addition, the acquired mtDNA A3243A/G somatic cell mutation rate in the T2DM carotid atherosclerosis group with the adiponectin gene SNP45 TT genotype was significantly lower compared with the SNP45 TG/GG genotype group. T2DM combined with carotid atherosclerosis was associated with long‑term oxidative stress. In addition, adiponectin gene SNP45 T/G was associated with increased mtDNA A3243A/G somatic mutation rates in T2DM patients with carotid atherosclerosis. Therefore, adiponectin gene polymorphisms may lead to diabetes atherosclerosis through oxidative stress.
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Piao et al. (2014) conducted a cross-sectional in Type 2 diabetes mellitus with and without carotid atherosclerosis (n=396). Adiponectin gene SNP45 TG/GG genotype vs. Adiponectin gene SNP45 TT genotype was evaluated on Acquired mtDNA A3243A/G somatic cell mutation rate (p=<0.05). In patients with type 2 diabetes and carotid atherosclerosis, the adiponectin gene SNP45 TG/GG genotype was associated with a significantly higher mtDNA A3243A/G somatic mutation rate (0.938%) compared to the TT genotype (0.279%).
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