Key result
Intrathecal bupivacaine extends sensory block duration by ~40 minutes and speeds onset vs levobupivacaine.
Why the study?
The onset and duration of sensory and motor blockade between intrathecal isobaric 0.5% bupivacaine and isobaric 0.5% levobupivacaine for infraumbilical surgeries were compared to address differences in anesthetic effects.
Does intrathecal isobaric levobupivacaine compared to isobaric bupivacaine affect the onset and duration of sensory and motor blockade in patients undergoing elective infraumbilical surgeries?
RCT (n=80)
Double-blind
Computerized generated randomization
No
Does intrathecal isobaric levobupivacaine compared to isobaric bupivacaine affect the onset and duration of sensory and motor blockade in patients undergoing elective infraumbilical surgeries?
Answers are grounded in this paper and cite their sources.
May favor bupivacaine for faster-onset, longer spinal anesthesia; hypothesis-generating and should not yet change practice.
Background: Spinal anaesthesia remains a popular technique of choice for performing surgeries on abdomen, pelvis and lower limbs. It has fast onset of action and provides effective sensory and motor blockade. Spinal anaesthesia is routinely performed by administration of 0.5% bupivacaine. Aims: Aim of the study was to compare onset and duration of sensory and motor blockade between intrathecal isobaric 0.5% bupivacaine and isobaric 0.5% levobupivacaine. Materials and methods: 80 patients between the age group of 18-65 years of either gender, belonging to ASA Grade I and II scheduled for elective infraumbilical surgeries were enrolled in the study. They were randomised into 2 groups. Group B received intrathecal 3.2 ml of 0.5 % isobaric bupivacaine and Group L received intrathecal 3.2 ml of 0.5% isobaric levobupivacaine. Onset and duration of sensory and motor blockage were compared between the two groups.
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Parthasarathy et al. (2022) conducted an RCT in Elective infraumbilical surgeries (n=80). Isobaric bupivacaine vs. Isobaric levobupivacaine (3.2 ml of 0.5%) was evaluated on Onset of sensory block (minutes) (p=<0.001). Intrathecal 0.5% isobaric bupivacaine provided a faster onset of sensory block and longer duration of sensory block compared to 0.5% isobaric levobupivacaine.
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