What question did this study set out to answer?

To assess the efficacy and clinical implications of direct-acting antiviral regimens for treating acute hepatitis C virus infection in patients coinfected with HIV.

December 13, 2013Clinical Infectious DiseasesOpen Access

Editorial Commentary: Management of Hepatitis C Virus in HIV-Infected Patients in the Era of Direct-Acting Antivirals

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To assess the efficacy and clinical implications of direct-acting antiviral regimens for treating acute hepatitis C virus infection in patients coinfected with HIV.
Commentary evaluating a prospective cohort of 19 HIV-positive men who have sex with men presenting with acute genotype 1 HCV infection in New York City.
Intervention evaluated a 12-week triple therapy regimen of telaprevir, pegylated interferon, and ribavirin compared to historical controls receiving pegylated interferon and ribavirin for 24–48 weeks (N=48).
Patients receiving 12-week telaprevir-based triple therapy achieved a sustained virologic response rate of 84% (16/19), compared to 62% (30/48) among controls receiving standard pegylated interferon and ribavirin for 24–48 weeks.
Incorporating direct-acting antivirals substantially shortened required treatment duration for acute hepatitis C while equalizing cure rates between HIV-coinfected and monoinfected individuals.

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Implication

Cohort study reveals improved sustained virologic response with shortened direct-acting antiviral therapy in HIV/HCV-coinfected men, suggesting acute-phase treatment can optimize cure rates.

Cite This Study

Zeremski et al. (2013) studied this question.

synapsesocial.com/papers/6aae04ae1491661de2a35821 https://doi.org/10.1093/cid/cit804

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Implication

Cohort study reveals improved sustained virologic response with shortened direct-acting antiviral therapy in HIV/HCV-coinfected men, suggesting acute-phase treatment can optimize cure rates.

Editorial Commentary: Management of Hepatitis C Virus in HIV-Infected Patients in the Era of Direct-Acting Antivirals

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Discussion

Implication

Cite This Study

Editorial Commentary: Management of Hepatitis C Virus in HIV-Infected Patients in the Era of Direct-Acting Antivirals

Key Points

Discussion

Implication

Cite This Study

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