Key result
Caveolin-2 over-expression increases caveolae in MDCK cells, indicating involvement in caveolar biogenesis.
Why the study?
The role of caveolin-2 in caveolar biogenesis in polarized MDCK cells was not fully understood.
Caveolin-2 plays a key role in caveolar biogenesis and the formation of caveolae on the basolateral membrane in MDCK cells.
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Extends cell-based evidence for caveolin-2; leaves open whether findings translate to cardiovascular disease models.
Lahtinen et al. (2003) studied MDCK cells. Caveolin mutant expression / Caveolin-2 over-expression was evaluated on Caveolar biogenesis. Over-expression of caveolin-2 in MDCK cells increased the number of caveolae, indicating the involvement of caveolin-2 in caveolar biogenesis.
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