A Caveolin Dominant Negative Mutant Associates with Lipid Bodies and Induces Intracellular Cholesterol Imbalance

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Population

Fibroblasts

Design

Preclinical

Authors

Discussion

Does not inform clinical lipid management; extends cellular mechanisms of cholesterol transport in model systems.

Population

Fibroblasts

Intervention

Expression of dominant negative caveolin mutant (cav-3(DGV))

Outcome

Intracellular cholesterol cycling and accumulationsurrogate

Caveolin plays a key role in intracellular cholesterol balance and lipid transport by associating with the membrane surrounding lipid droplets.

Pol et al. (2001) studied this question.

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